Microparticle Generation in a Rabbit DIC Model

Microparticle Generation in Vitro and in Vivo

Disseminated intravascular coagulation (DIC) in rabbit haemorrhagic disease.

Seven rabbits experimentally infected with rabbit haemorrhagic disease virus were examined haematologically and histologically. Haematologically, activated partial thromboplastin time and prothrombin time were markedly prolonged in the terminal phase of the disease, just prior to death (all the animals died between 27 and 40 hr after inoculation with rabbit haemorrhagic disease virus). There wa...

A DIC-based Distributed Algorithm for Frequent Itemset Generation

A distributed algorithm based on Dynamic Itemset Counting (DIC) for generation of frequent itemsets is presented by us. DIC represents a paradigm shift from Apriori-based algorithms in the number of passes of the database hence reducing the total time taken to obtain the frequent itemsets. We exploit the advantage of Dynamic Itemset Counting in our algorithmthat of starting the counting of an i...

Role of P2Y receptor subtypes in platelet-derived microparticle generation.

Microparticles are shed from the platelet membrane upon platelet activation by strong agonists, and they aid in clot formation. As the P2Y1 and the P2Y12 receptors differentially contribute to different platelet functions, we studied the relative contribution of the P2Y1 and P2Y12 receptors to microparticle formation from platelets. The P2Y12 receptor antagonist AR-C 69931MX, but not the P2Y1 r...

Microparticle generation and leucocyte death in Shiga toxin-mediated HUS.

BACKGROUND Shiga toxin-induced haemolytic uraemic syndrome (STEC-HUS) is an acute multisystem disorder characterized by renal failure, neurological dysfunction, haemolysis and intravascular thrombosis. Circulating microparticles originating from a number of cell types including thrombocytes and leucocytes are elevated in paediatric patients. In vitro data also suggest modification of leucocyte ...